«IZVESTIYA IRKUTSKOGO GOSUDARSTVENNOGO UNIVERSITETA». SERIYA «PSICHOLOGIYA»
«THE BULLETIN OF IRKUTSK STATE UNIVERSITY». SERIES «PSYCHOLOGY»
ISSN 2304-1226 (Print)

List of issues > Series «Psychology». 2025. Vol 54

Psychological and Psychophysiological Factors of the Use of Assisted Reproductive Technologies in the Treatment of Infertility in Women: A Systemic Review

Author(s)

D. V. Yasnaya1

1Kemerovo State University, Kemerovo, Russian Federation

Abstract
The article presents a systematic review of foreign studies of psychological and physiological factors-predictors of assisted reproduction technology efficiency. A systematic analysis of papers in 2020–2025 published in electronic bibliographic databases Google Scholar, PubMed. Based on selection criteria 18 articles have been chosen for the final analysiss. The papers contain contradictory data, while objective psychophysiological and biochemical markers of stress show a more evident relation to the results than subjective psychological evaluation. This review demonstrates the need for standardization of research protocols and development of complex, multimodal evaluation strategies integrating psychological and psychophysiological methods.
About the Authors
Yasnaya Darya Vladimirovna, Senior Lecturer, Department of Psychology and General Pedagogy, Kuzbass Humanitarian and Pedagogical Institute Kemerovo State University 6, Krasnaya st., Kemerovo, 650043, Russian Federation e-mail: st1daria@ya.ru
For citation
Yasnaya D.V. Psychological and Psychophysiological Factors of the Use of Assisted Reproductive Technologies in the Treatment of Infertility in Women: a Systemic Review. The Bulletin of Irkutsk State University. Series Psychology, 2025, vol. 54, pp. 90-102. https://doi.org/10.26516/2304-1226.2025.54.90 (in Russian)
Keywords
infertility, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), stress, anxiety, depression.
UDC
159.91+618.177-089.888.11+612.821
DOI
https://doi.org/10.26516/2304-1226.2025.54.90
References
  1. Birukova A.M. et. al. Diagnostika i lechenie besplodiya. Klinicheskaya lektsiya [Infertility diagnosis and treatment. Clinical lecture]. Meditsinskiy Opponent [Medical Opponent], 2021, no. 2 (14), pp. 41-45. (in Russian) 
  2. Yasnaya D.V. et al. Psikhoemotsionalnye sostoyaniya zhenshchin, prokhodyashchikh lechenie metodom ekstrakorporalnogo oplodotvoreniya [Psychoemotional states of women undergoing in vitro fertilization treatment]. Akusherstvo i Ginekologiya [Obstetrics and Gynecology], 2025, no. 3, pp. 136-143. https://doi.org/10.18565/aig.2024.310 (in Russian) 
  3. Filippova G.G. (Stress i narushenie reproduktivnoi funktsii [Stress and reproductive dysfunction]. Antologiya rossiiskoi psikhoterapii i psikhologii [Anthology of Russian Psychotherapy and Psychology]. Proceedings of the International Congress of the National Self-regulatory Organization “Union of Psychotherapists and Psychologists”, November 15-18, 2018. Ed. by Makarov V.V., Kamalova S.Ts., Bulycheva A.E. Moscow, 2018, pp. 69-72. (in Russian) 
  4. Szabo G. et al. Affective temperaments show stronger association with infertility treatment success compared to somatic factors, highlighting the role of personality focused interventions. Scientific Reports, 2023, vol. 13. https://doi.org/10.1038/s41598-023-47969-x 
  5. Li Y. et. al. Anxiety in couples undergoing IVF: evidence from E-Freeze randomised controlled trial. Human Reproduction Open, 2024, vol. 2024, no. 3. https://doi.org/10.1093/hropen/hoae037
  6. Aspiotis V. et al. Assessing electroencephalography as a stress indicator: a VR high-altitude scenario monitored through EEG and ECG. Sensors, 2022, vol. 22. https://doi.org/10.3390/s22155792
  7. Bolton D., Grant G. The Biopsychosocial Model of Health and Disease. Cham, Palgrave Macmillan Cham, 2019, 149 p. https://doi.org/10.1007/978-3-030-11899-0
  8. Cao D., Bai C., Zhang G. Psychological distress among infertility patients: a network analysiss. Frontiers in Psychology, 2022, vol. 13. https://doi.org/10.3389/fpsyg.2022.906226 
  9. Chai Y. et al. Cortisol dysregulation in anxiety infertile women and the influence on IVF treatment outcome. Frontiers in Endocrinology, 2023, vol. 14. https://doi.org/10.3389/fendo.2023.1107765
  10. Showkath N. et al. EEG-ERP correlates of cognitive dysfunction in polycystic ovarian syndrome. Annals of Neurosciences, 2022, vol. 29, pp. 225-232. https://doi.org/10.1177/09727531221115318
  11. Bian Y. et al. Effects of heart rate variability (HRV) biofeedback for women undergoing firsttime in vitro fertilization and embryo transfer. Alternative therapies in health and medicine, 2023, vol. 29, pp. 162-167. 
  12. Zhu H. et al. Global research trends on infertility and psychology from the past two decades: a bibliometric and visualized study. Frontiers in Endocrinology, 2022, vol. 13. https://doi.org/10.3389/fendo.2022.889845 
  13. Devroe J. et al. Great expectations of IVF patients: the role of gender, dispositional optimism and shared IVF prognoses. Human Reproduction, 2022, vol. 37, pp. 997-1006. https://doi.org/10.1093/humrep/deac038
  14. Santa-Cruz D.C. et al. Hair cortisol concentrations as a biomarker to predict a clinical pregnancy outcome after an IVF cycle: a pilot feasibility study. International Journal of Environmental Research and Public Health, 2020, vol. 17. https://doi.org/10.3390/ijerph17093020
  15. Lewinski A., Brzozowska M. Female infertility as a result of stress-related hormonal changes. Gynecological and Reproductive Endocrinology and Metabolism, 2022, vol. 3, pp. 94-98. https://doi.org/10.53260/grem.22302035
  16. Ozcelik B., Karamustafalioglu O., Ozcelik A. The psychological and psychiatric aspects of infertility. Alpha Psychiatry, 2007, vol. 8, pp. 140-148. 
  17. Cui Y. et al. Prospective study of pregnancy outcome between perceived stress and stressrelated hormones. Journal of Obstetrics and Gynaecology Research, 2020, vol. 46, pp. 1355-1363. https://doi.org/10.1111/jog.14278
  18. Neto R.B. et al. Psychosocial aspects of infertility and the impact of assisted reproductive techniques – a comprehensive review. JBRA Assisted Reproduction, 2025, vol. 29, pp. 378-393. 
  19. Sharma A., Shrivastava D. Psychological problems related to infertility. Cureus, 2022, vol. 14. https://doi.org/10.7759/cureus.30320
  20. Peng M. et al. Stress, anxiety, and depression in infertile couples are not associated with a first IVF or ICSI treatment outcome. BMC Pregnancy and Childbirth, 2021, vol. 21. https://doi.org/10.1186/s12884-021-04202-9
  21.  Attar E.T. et al. Stress analysis based on simultaneous heart rate variability and EEG monitoring. IEEE Journal of Translational Engineering in Health and Medicine, 2021, vol. 9, pp. 1-7. https://doi.org/10.1109/JTEHM.2021.3106803
  22. Geisler M. et al. Stress and the impact on the outcome of medically assisted reproduction. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2020, vol. 248, pp. 187-192. https://doi.org/10.1016/j.ejogrb.2020.03.006
  23. Tuncay G. et al. Stress in couples undergoing assisted reproductive technology. Archives of Gynecology and Obstetrics, 2020, vol. 301, pp. 1561-1567. https://doi.org/10.1007/s00404-020-05549-8
  24. Koumparou M. et al. Stress management and In Vitro Fertilization (IVF): a pilot randomized controlled trial. Psychiatriki, 2021, vol. 32, pp. 290-299. https://doi.org/10.22365/jpsych.2021.029
  25. Bezerra N.K. et al. Success of in vitro fertilization and its association with the levels of psychophysiological stress before and during the treatment. Health Care for Women International., 2020, vol. 42, pp. 420-445. https://doi.org/10.1080/07399332.2020.1787415 
  26. Swanson A., Braverman A.M. Psychological components of infertility. Family Court Review, 2021, vol. 59, pp. 67-82. https://doi.org/10.1111/fcre.12552
  27. Trikoilis N. et al. The association of in vitro fertilization/inntracytoplasmic sperm injection results with anxiety levels and stress biomarkers: An observational, case-control study. Journal of Gynecology Obstetrics and Human Reproduction, 2022, vol. 51, no. 1. https://doi.org/10.1016/j.jogoh.2021.102254
  28. Simionescu G. et al. The complex relationship between infertility and psychological distress (Review). Experimental and Therapeutic Medicine, 2021, vol. 21. https://doi.org/10.3892/etm.2021.9737
  29. Aimagambetova G. et al. The effect of psychological distress on IVF outcomes: reality or speculations. PLoS One, 2020, vol. 15, no. 12. https://doi.org/10.1371/journal.pone.0242024
  30. Bapayeva G. et. al. The effect of stress, anxiety and depression on in vitro fertilization outcome in Kazakhstani public clinical setting: a cross-sectional study. Journal of Clinical Medicine, 2021, vol. 10, no. 5. https://doi.org/10.3390/jcm10050937
  31. Mirzaasgari H. et al. The relationship between coping strategies and infertility self-efficacy with pregnancy outcomes of women undergoing in vitro fertilization: a prospective cohort study. International Journal of Reproductive BioMedicine, 2022, vol. 20, pp. 539-548. https://doi.org/10.18502/ijrm.v20i7.11556
  32. Mirzaasgari H. et al. The role of psychological distress in the relationship between personality dimensions and pregnancy outcome of women undergoing assisted reproductive treatment (IVFCSI). Iranian journal of psychiatry, 2023, vol. 18, pp. 153-164. https://doi.org/10.18502/ijps.v18i2.12366
  33. Wischmann T. Psychological aspects of infertility. Medizinische Genetik, 2024, vol. 36, pp. 171-177. https://doi.org/10.1515/medgen-2024-2029 
  34. Minguez-Alarcon L. et al. Women's preconception psychological stress and birth outcomes in a fertility clinic: the EARTH study. Frontiers in Global Women's Health, 2024, vol. 5. https://doi.org/10.3389/fgwh.2024.1293255
  35. Hazlina N.H.N. et al. Worldwide prevalence, risk factors and psychological impact of infertility among women: a systematic review and meta-analysiss. BMJ Open, 2022, vol. 12. https://doi.org/10.1136/bmjopen-2021-057132



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