The paper presents the results psycho-physiological study of Biology and Soil Studies 1st – 4th year students’ level of regulatory system tension and efficiency of the cen-tral nervous system as well as subjective assessment of their functional status before and after the study. Most of 1st – 3rd year students show performance decrement of central nervous system after study, with students of first and fourth year regulatory mechanism tension however is more evident. The results show that first year students are more tended to be effected by various factors. To prevent psychosomatic disturbances within this group of students adaptation measures are necessary.